Protective effects of intracranial stimulation on spatial memory and changes in miRNA serum levels in a sporadic rat model of Alzheimer disease: A longitudinal study
Andrea Riberas Sánchez, Soleil Garcia Brito, Gemma Carreras Badosa, Laia Vila Solés, Laura Aldavert Vera, Pilar Segura Torres, Gemma Huguet Blanco, Elisabet Kádár Garcia · FENS Forum 2024
Alzheimer’s disease (AD) is the most prevalent ageing-associated neurodegenerative disease. Deep brain stimulation is a novel therapeutic approach, but long-term effects remain unknown. We previously demonstrated that acute intracranial self-stimulation (ICSS) in medial forebrain bundle (MFB) improves the acquisition but not 72-hour retention of a spatial learning task and regulates expression of specific miRNAs in a rat AD model. This study aims to analyse the effect of a chronic MFB-ICSS treatment on spatial memory and miRNA serum expression levels in a rat AD model by streptozotocin (STZ) i
ePoster · Neuroscience