microRNAs regulating CaMKIIα/SIRT1 signaling pathway are associated with cognitive ability and academic performance in adolescents
Li-Ching Lee, Ming-Tsan Su, Lei Bao, Ting-Kuang Yeh, Chun-Yen Chang · FENS Forum 2024
Calcium-calmodulin (CaM)-dependent protein kinase IIα (CaMKIIα) is a central player of molecular memory and cognitive function. It is stimulated by Ca2+/CaM binding and subsequently generates Ca2+-independent autonomous activity. Multiple signaling pathways have been shown to regulate the expression and activity of CaMKIIα. However, the mechanisms by which CaMKIIα controls long-term potentiation (LTP) or long-term depression (LTD), which are involved in learning and memory, remain obscure. Our recent study found that the expression of the CaMKIIα can be regulated by microRNAs (miRNAs). To furt
ePoster · Neuroscience