The role of the X-linked cyclin dependent kinase like 5 (CDKL5) gene in extracellular vesicle-mediated cell-to-cell communication
Antonia Gurgone, Vita Cardinale, Debora Comai, Giuseppe Chiantia, Riccardo Pizzo, Francesca Anselmi, Andrea Lauria, Salvatore Oliviero, Maurizio Giustetto · FENS Forum 2024
Cyclin dependent kinase like 5 (CDKL5) deficiency disorder (CDD) is a syndromic autism-spectrum condition with a broad constellation of severe cognitive, sensory-motor and autonomic deficits. Mutations on CDKL5 gene lead to abnormalities of neuronal and synaptic maturation in both CDKL5 mouse mutants and CDD human brains. These abnormalities can be recapitulated by defects in cell-to-cell communication mechanisms, such as for instance those mediated by extracellular vesicles (EVs), lipid-enclosed nanoparticles secreted by all cells, which content reflects the physiological or pathological cond
ePoster · Neuroscience