Topic: mismatch responses

Sensory systems in the mammalian brain exhibit rich representations that ultimately support complex behaviours. Microcircuits across neocortical layers are believed to underlie the development of these representations, but exactly how this occurs remains unclear. In the canonical view of the neocortical microcircuit, first-order thalamic projections target layer 4 (L4), which in turn projects onto layer 2/3 (L2/3) pyramidal cells (PCs) and then finally onto layer 5 (L5) PCs. Although this is a motif found throughout the neocortex, the functional role of this architecture is not known. Here, in