Normalization of the accumbal cell type-specific transcriptomic signatures and anxiety-like behaviour following treatment with a mitochondrial booster in outbred rats
Dogukan Ulgen, David Mallet, Carmen Sandi · FENS Forum 2024
The nucleus accumbens (NAc), a central hub in reward processing, intricately modulates emotional behaviours, including anxiety. A compound derived from the metabolization of polyphenols by the microbiota, mitobooster (MB) has been previously shown to improve mitochondrial function by promoting turnover of the dysfunctional mitochondria. In this study, we aimed to understand the effect of MB treatment in outbred rats that show high anxious-like behaviour. First, animals were grouped by their trait anxiety based on the amount of time spent in the open arms in the elevated plus maze test, and the
ePoster · Neuroscience