Topic: mitochondria-derived metabolites

Neurogenesis is the process by which dividing neural stem/progenitor cells (NSPCs) produce post-mitotic cells. The balance between self-renewal and differentiation is a highly controlled process under the influence of intrinsic and extrinsic factors. Previous studies have pointed to a model whereby cell fate is largely determined before the last mitosis. However, recent findings indicate that in the cerebral cortex mitochondrial dynamics have an impact on neurogenesis after the last cell division. Daughter cells with high levels of mitochondrial fusion undergo self-renewal, whereas those cells