Topic: mitochondrial-ER contact sites

Following injury, astrocytes undergo major alterations in morphology and gene expression, leading to the acquisition of distinct “reactivity” states that play important roles in brain tissue repair. Evidence indicates that these cellular states are also marked by rewiring of mitochondrial energy metabolism, i.e. the central hub for cellular energy metabolism and metabolic signaling. However, how such mitochondrial responses are regulated and how they may influence astrocyte reactivity remains unclear. Our prior research unveiled temporal and region-specific morphological changes in astrocytic