Topic: mitochondrial fatty acid beta-oxidation

Energy metabolism in the brain accounts for approximately 20% of the body’s oxygen consumption being glutamatergic transmission a major contributor. To meet these energetic requirements there is a tight coupling between neurons and astrocytes. Thus, neuronal glutamatergic activity decreases astrocytic oxidative glucose metabolism in favor of glucose metabolism to lactate. Lactate released by astrocytes can be oxidatively metabolized by neurons. However, little is known about the interplay between neuronal activity and astrocytic metabolism concerning other energetic sources. Here, we made use