Unravelling the role of CHCHD2 in mitochondrial dysfunction: Implications for Parkinson's disease and beyond
Jule Gerlach, Paola Pireddu, Simon Wetzel, Xiaoqun Zhang, Mara Mennuni, Rodolfo Garcia Villegas, Diana Rubalcava-Gracia, David Alsina, Per Svenningsson, Filograna Roberta · FENS Forum 2024
Parkinson’s disease (PD) is a debilitating neurodegenerative disorder characterized by the preferential loss of dopaminergic neurons in the Substantia nigra resulting in a dopamine (DA) depletion in the striatum and subsequential motor impairment in patients. Increasing evidence has linked mitochondrial dysfunction to PD; however, the underlying molecular mechanisms remain unclear. Recently, mutations in CHCHD2 gene have been identified in PD patients. CHCHD2 belongs to a family of evolutionary conserved mitochondrial protein, which act as regulators of mitochondrial ultrastructure and dynamic
ePoster · Neuroscience