Protective effect of the magnetic stimulation in 6-OHDA-induced Parkinson's disease model in vitro
Teodora Martić, Milena Milošević, Katarina Stevanović, Nebojša Jasnić, Ivana Stevanović, Nadežda Nedeljković, Milorad Dragić, Marija Adžić Bukvić · FENS Forum 2024
Parkinson's disease (PD) is the second most common neurodegenerative disease, manifested by the loss of dopaminergic neurons. It has been shown that oxidative stress and apoptosis play a major role in the pathology of PD. One of the most commonly used models for in vitro investigation of PD is the SH-SY5Y neuroblastoma cell line and application of hydroxydopamine (6-OHDA). The 6-OHDA exerts its cytotoxicity by generating reactive oxygen species (ROS) such as hydrogen peroxide, superoxide anion and hydroxyl-radical, leading to oxidative stress by disrupting the mitochondrial membrane integrity,