Mirtazapine treatment of maternal depression – positive effect on the offspring development?
Katarína Ondáčová, Stanislava Bukatová, Zuzana Ševčíková-Tomášková, Alžbeta Idunková, Lucia Dubiel-Hoppanová, Marián Grman, Michal Dubovický, Ľubica Lacinová · FENS Forum 2024
Antidepressant treatment during pregnancy may endanger neurodevelopment of the offspring. Cellular parameters (hippocampal homeostasis) and physiological parameters (behavioral aspects) in the offspring of Mirtazapine treated and depressed mothers are not yet fully described. We evaluated changes in cellular calcium homeostasis (Fura2AM) and CaV1.2 expression, presence of mitochondrial superoxide radicals (MitoSOXTM) together with behavior of developing pups.As an experimental model of perinatal depression we used pre-gestational exposure to chronic unpredictable stress followed by Mirtazapine
ePoster · Neuroscience