Topic: mitochondrial targeting

Amyotrophic lateral sclerosis (ALS) is a fatal and non-curable neurodegenerative disease for which the etiology remains poorly understood. However, among the pathophysiological hallmarks observed both in patients and in animal models, mitochondrial dysfunctions appear to be one of the earliest events and thus might be causative for the progressive loss of motor neurons (Le Masson et al, 2014). Therefore, restoring mitochondrial functions could be a therapeutic area of interest in the development of new therapies in the context of ALS.For this purpose, we are interested in the Bornavirus X prot