Effect of alpha-synuclein on the expression of genes encoded in mitochondrial DNA
Bilge Nur Bilge, Tugay Çamoğlu, Zuhal Yurttaş, Sümeyra Ildız, Nazlıcan İlhan, Erdinç Dursun, Duygu Gezen Ak · FENS Forum 2024
Mitochondrial dysfunctions are common findings in neurodegenerative diseases, particularly in Parkinson's disease(PD), where alpha-synuclein encoded by the SNCA gene has been observed to localize within the organelle as the disease progresses. Despite alpha-synuclein's significance in PD pathology, its specific roles within mitochondria still need to be better understood. In this study, we aimed to explore the impact of overexpression of the SNCA gene, which codes for the alpha-synuclein protein, on the expression of genes encoded by mitochondrial DNA (mtDNA).HEK-293T cells were transfected wi
ePoster · Neuroscience