Optogenetically de-energized mitochondria of parvalbumin-positive interneurons impair spatial properties within the CA1 region of the hippocampus
Rina Patel, Silvia Viana da Silva, Matthias Haberl · FENS Forum 2024
Parvalbumin-positive (PV+) interneurons within the hippocampal system are crucial for maintaining spatial memory functions that are otherwise impaired in neurodegenerative diseases. To maintain such an extensive control, PV+ interneurons require a high energy demand, which requires highly functional mitochondria. Previous studies have shown dysregulations of mitochondria within the hippocampus (HPC) are apparent early on in cases of Alzheimer’s Disease (AD), even preceding the major pathological hallmarks: tau aggregation, amyloid-beta plaques, and impairments in memory. Optogenetic tools have
ePoster · Neuroscience