Histone H3 variants are associated with distinctive glioma entities
Luis M. Valor, Anabel Garcia-Heredia, Estefania Rojas, Artemio Paya, Luna Guerra-Nuñez, Paula Martin-Climent, Inmaculada Catalina-Fernández, Irati Hervas-Corpion, Jorge Navarro-Calvo, Pablo Gonzalez-Lopez, Irene Iglesias-Lozano, Jose L. Gil-Salu, Cristina Alenda · FENS Forum 2024
Gliomas constitute a heterogeneous group of primary brain cancers, being glioblastoma (GBM) the most prevalent and aggressive form. Despite intensive research, current biomarkers and therapies are still not applied in a personalized manner, and do not prevent recurrency. H3.3 is a non-canonical, replication-independent histone H3 variant which alterations have gain- and loss-of-function effects in pediatric and adult GBM, respectively. The canonical replication-dependent H3.1/H3.2 variants remain largely unexplored in gliomas. We examined these variants in surgical resections of two independen
ePoster · Neuroscience