Quenching mitochondrial reactive oxygen species in oligodendrocytes protects axonal function in aging and neuroinflammatory disease
Urvashi Dalvi, Juan Villar Vesga, Fiona Seitz, Henri Zanker, Richard Fairless, Sarah Williams, Juan Bolanos, Bruno Weber, Sarah Mundt, Aiman Saab · FENS Forum 2024
Oligodendrocytes (OLs) myelinate axons and are essential for fast impulse propagation and the brain’s remarkable processing power. They also carry out important homeostatic support functions that are critical for maintaining long-term neuronal integrity. Mitochondrial reactive oxygen species (ROS) are implicated in various neurodegenerative diseases and influence cell functions in a cell-specific manner, yet the (patho)physiological impact of oligodendroglial ROS on neural functions remains unknown. To study the impact of oligodendroglial ROS in aging and disease, we generated mice (termed OL-
ePoster · Neuroscience