Brain activation during inflammatory and non-inflammatory hyperalgesia in a rheumatoid arthritis mouse model
Rita Gálosi, Gábor Kriszta, Éva Borbély, Ádám I Horváth, Valéria Tékus, Nikolett Szentes, Zsuzsanna Helyes · FENS Forum 2024
The K/BxN serum-induced arthritis mouse model is used as a human rheumatoid arthritis (RA) model. Previous results demonstrated that after the arthritogenic K/BxN serum injections joint edema and inflammation are pronounced for 9 days, then decrease, while hyperalgesia persists. We applied manganese-enhanced magnetic resonance imaging (MEMRI) after arthritogenic K/BxN or non-arthritogenic BxN serum administration on days 9 and 21, to detect pain-related brain activity reflecting the inflammatory and non-inflammatory phases of this model. MRI scans were conducted before and 24 hours after the M
ePoster · Neuroscience