ePoster · Neuroscience
AutSim: Principled, data driven model development and abstraction for signaling in synaptic protein synthesis in Fragile X Syndrome (FXS) and healthy control.
Nisha Viswan,Upinder Bhalla · COSYNE 2022
Sat, Mar 19, 2022
Data provenance and model complexity are recurring challenges when simulating neural function, particularly signaling, at the level of detail needed to address disease conditions. Here we report a data-driven modeling and model abstraction framework applied to ~40 signaling pathways involved in translation and FXS. FXS is an X-linked neurodevelopmental disorder caused by the loss of FMRP which is an essential regulator for local translation at synapses. Bowling et al., 2019 had suggested that the de-novo translation profiles tend to differ in FXS mouse at steady-state and in the presence of mG