NMDAR blockade impairs cognitive control necessary for evidence accumulation and short-term memory
Alexis Cerván, Tiffany Oña-Jodar, Genís Prat-Ortega, Josep Dalmau, Albert Compte, Jaime de la Rocha, Carles Sindreu · FENS Forum 2024
During perceptual decision-making, neural circuits can accumulate decision evidence and maintain the choice in short-term memory until the motor response. Previous modelling work has proposed that recurrent circuit dynamics underlie these two processes and that N-methyl-D-aspartate receptors (NMDARs) are necessary for proper network function. Electrophysiological evidence indicates that circuits in the frontal cortex may carry out these computations but the role of NMDAR has not been systematically tested. We developed an auditory two-alternative delayed-choice (2ADC) task for head-fixed mice
ePoster · Neuroscience