Topic: modulatory neurons

The human brain quickly adapts to a rapidly changing environment, often faster than what is thought to be possible by way of synaptic plasticity. Real-time control adaptation can only be achieved through faster processes such as neuromodulation. A number of neuromodulation models based on gain regulation have been proposed recently. But most of them utilize neuron-wide regulation and can not accommodate the simultaneous impact of different types of neurotransmitters on different parts of the dendritic tree. Models of synaptic gating and connectivity-tuning demonstrate that using enough additio