Topic: molecular alterations

Long-term depression (LTD) is an activity-dependent decrease of synaptic strength. This depressed state is transient, initiating either a re-potentiation or suppression, referred to as pruning, of the synapse within hours to days following the LTD induction. Nevertheless, the precise relationship between LTD and synaptic pruning remains incompletely elucidated. Through the integration of various imaging techniques and electrophysiology, we have identified essential factors that link NMDAR-dependent LTD to synaptic pruning. The molecular alterations pivotal for the induction of LTD must persist