Topic: molecular convergence

Autism spectrum disorders (ASD) are associated with a high genetic heterogeneity, yet for many of the cases, the underlying molecular causes remain elusive. While several studies have elucidated some distinct patterns, fundamental questions persist: How do mutations dispersed across numerous genes lead to the development of a phenotypically similar disorder? Essentially, it remains largely unclear whether mutations in distinct genes lead to similar molecular and cellular states within the brain. Thus, it is important to identify molecular mechanisms responsible aiming to decipher points of con