Topic: molecular markers

Neuropsychiatric disorders are prevalent diseases whose causes and mechanisms remain unknown due to its complexity. In this context, translating experimental findings from humans to the clinic represents a major challenge that new technologies are assessing. Here we propose the use of a neurohistopathology pipeline to perform systematic multiscale analysis of pathological human brains and identify the cellular, molecular and circuit underpinnings of neurodegenerative and psychiatric disorders. We have developed and adapted new tissue clearing and labeling techniques in large scale samples, whi