Topic: monoamine neurons

Recent preclinical and clinical observations identified alterations in the midbrain along the prodromal phase of Alzheimer’s disease (AD). These alterations include degeneration of monoamine neurons, resulting in deficits in ascending monoaminergic pathways in target areas related to AD, as the hippocampus. Incidentally, recent findings link the role of monoamines in the modulation of neuroinflammation.Here we sought to prove how the degeneration of the midbrain, leading to monoamine loss in the hippocampus, activates a neuroinflammatory response, in addition to alterations of synaptic plastic