Topic: Monoamine neurotransmitter transporters

Monoamine neurotransmitter transporters (MAT) are a class of membrane proteins that fine-tune synaptic transmission by reuptaking monoamines after synaptic release, making them important molecular targets. Amphetamine-like substrates reverse the transport direction of MAT and trigger unrestrained neurotransmitter release in an exocytosis-independent manner, leading to several unwanted effects. Partial efficacy refers to a ligand's ability to induce less than maximal response with the protein of interest. While partial efficacy at G protein-coupled receptors (GPCRs) has been extensively describ