Topic: monocyte-derived macrophages

Spinal cord injury (SCI) in mammals leads to a series of cellular and molecular changes affecting self-repair. The breakdown of the blood-spinal cord barrier allows immune cells infiltration secreting various cytokines that, together with neural cells particularly activated microglia, will spread inflammation and aggravate the neurological deficits. Infiltrated immune cells include neutrophils, monocyte-derived macrophages, and T-cells. Most of preclinical studies evaluated this response in two SCI models: contusion (CT) and transection (TS); having distinct mechanical action modes on spinal c