Communication between the suprachiasmatic nucleus and the subparaventricular zone of the hypothalamus
Francesca Raffin, Oscar Ramirez Plascencia, Roberto De Luca, Patrick M. Fuller, Gerardo R. Biella, Elda Arrigoni · FENS Forum 2024
The suprachiasmatic nucleus (SCN) is the central circadian clock, governing physiological processes through its output to the subparaventricular zone (SPZ). We investigated functional synaptic connectivity between the SCN and the SPZ neurons in mouse brain slices and we studied the effects of peptides expressed in the SCN on the SPZ neurons. Photostimulation of SCN neuromedin-S (NMS) neurons or the vasoactive intestinal peptide (VIP) neurons induced opto-evoked inhibitory post-synaptic currents (oIPSCs) in 60% and 50% of recorded SPZ neurons, respectively. These responses were mediated by GABA
ePoster · Neuroscience