Topic: monosynaptically-connected brain regions

Neuronal ensembles encoding a specific memory have been shown to be distributed across multiple brain regions. However, the computational principles behind the distributed nature of such memory engrams are unknown. Here we propose that distributed engrams support functional flexibility and versatility. We investigated whether distributed engrams can differentially regulate memory discrimination and generalization, opposing and complementary computations that must be balanced for adaptive memory-guided behavior. For instance, while animals need to discriminate between threat-predictive and neut