Ventral striatal control of spatial memory consolidation in the hippocampus
Mattia Santoboni, Eleonora Centofante, Caterina Stacchiola, Silvia Gasparini, Elena Mombelli, Francesca De Iuliis, Arianna Rinaldi, Andrea Mele · FENS Forum 2024
New spatial representations are initially encoded in a labile form by the hippocampus (HPC) and cansubsequently either be lost or stabilized into permanent traces. There is a suggestion that signals originatingfrom the VTA to the HPC play a significant role in this process. We tested the hypothesis that the VTA’sinfluence on memory persistence in the HPC could be modulated by inputs from the ventral striatum (VS).Utilizing transgenic mice expressing a Cre-dependent reporter dTomato, we verified the existence of anindirect pathway from the VS to the HPC via the VTA. For this purpose, we injecte
ePoster · Neuroscience