Evaluation of the effects of taurine treatment on apoptotic processes, miR-34a, oxidative stress, and inflammatory markers in intracerebroventricular Amyloid Beta 1-42 injected rats
Burak Kayabasi, Nida Aslan Karakelle, Sibel Dincer · FENS Forum 2024
We aimed to investigate the effect of taurine especially on apoptosis and also inflammatory and oxidative processes in an Alzheimer-like disease model induced by intracerebroventricular(icv) Amyloid Beta 1-42(Aβ1-42) injection.30 Wistar Albino rats were divided into 4 groups: Control(n:7), Taurine(n:7), icv Aβ1-42(n:8), icv Aβ1-42+taurine(n:8). After administration of icv Aβ1-42 to the relevant groups, taurine groups received taurine by oral gavage at 250 mg/kg/day for 32 days. Rats were sacrificed on day 33. Analysis were performed on rat brain tissue. To evaluate the apoptosis bax, bcl-2, cl
ePoster · Neuroscience