Topic: mossy fiber synapses

The hippocampus is known to play a major role in the storage and recall of information depending on various forms of activity dependent synaptic plasticity. Mossy fiber synapses between the axons of dentate gyrus (DG) granule cells and CA3 pyramidal cells (Mf-CA3 synapses) display a high dynamic range of presynaptic plasticity which endow these synaptic connections with detonator properties. The pattern of action potential firing, in the form of high frequency bursts in the DG, strongly controls the amplitude of synaptic responses and information transfer to CA3. Presynaptic short-term plastic