Frequency- and layer-specific effects of high-frequency STN stimulation on mouse motor cortical areas in vivo
Svenja Kreis, Gabriel Gonzalez-Escamilla, Daniela Mirzac, Muthuraman Muthuraman, Heiko Luhmann, Sergiu Groppa · FENS Forum 2024
High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective evidence-based therapy for Parkinson's disease, however, its effects on the motor network are unclear. In anaesthetized mice we studied the layer- and frequency-specific effects of DBS on the connectivity between STN and rostral and caudal forelimb area (RFA and CFA) layers, the respective homologs to human premotor and motor cortex. Multi-site extracellular recordings served to quantify local field potential-driven activity at rest and during burst STN stimulation at multiple stimulation-freqeuncies f
ePoster · Neuroscience