Real-time imaging of dopamine release and neuronal population dynamics in the motor cortex of awake mice – decoding of reward-related signals and movement parameters
Martyna Gorkowska, Gniewosz Drwiega, Lukasz Szumiec, Jan Rodriguez Parkitna, Przemyslaw Eligiusz Cieslak · FENS Forum 2024
Motor cortex (MCtx) comprise the primary descending circuits for flexible control of voluntary movements and plays an important role in motor skill learning. The proposed mechanism for motor learning and updating is dopaminergic modulation of local neuronal activity. However, little is known about the organization of dopaminoceptive circuits in the MCtx. Therefore, we targeted cells expressing D1 and D2 receptors in the MCtx and discovered that neurons located in the superficial layer 2/3 have D2 receptors, whereas the majority of cells in deep output layers 5-6 express D1 receptors. We then i
ePoster · Neuroscience