Topic: movement preparation

To understand the cortical control of complex limb movements, we must identify how movement control signals differ across different sensorimotor regions. Here we characterize the structure of movement-related activity across 6 subregions of primary and secondary motor (M1 and M2) and primary somatosensory cortex (S1) in the mouse. To evoke coordinated forelimb movements, we developed a reach-to-grasp task in which head-fixed mice performed delayed reaches to 15 distinct target locations. We performed two-photon calcium imaging in layer 2/3 of each area (>8,000 neurons, 19 sessions, 4 mice). Th