Nestin+ cells interaction with microglia and astrocytes in perivascular space of malignant peripheral nerve sheath tumors
Susana Bulnes, Aitor Jauregi, Harkaitz Bengoetxea, Naiara Ortuzar, José Vicente Lafuente · FENS Forum 2024
Malignant peripheral trigeminal sheath tumor (MPNST) spreads to the brain parenchyma via the perivascular space (PVS). Nestin-expressing neoplastic cells lead tumor progression. Tumor-associated macrophages and microglia (TAMs) are a critical immune cells population for promoting this progression. In this work, we study the distribution of Nestin+ cells and TAMs in the infiltrative perivascular spaces of endogenous rat MPNSTs.MPNSTs are induced in Sprague Dawley rats by prenatal exposure of N-Ethyl N-nitrosourea (ENU). Tumor screening is performed by T1-w Magnetic Resonance Imaging and by immu
ePoster · Neuroscience