Topic: MPTP-induced PD model

Parkinson’s disease (PD) is a neurodegenerative disorder that is characterized by dopaminergic neuronal damage. We evaluated the neuroprotective effect of γ-amino butyric acid (GABA) in PD and the underlying mechanism focusing on WNT/β-catenin signaling mediated by the MAPK pathway. We treated MPTP-induced SH-SY5Y cells with GABA Low and High concentrations, and we also treated PD model mice with GABA. GABA treatment effectively reduced the expression of biomarkers associated with PD, particularly lewy’s bodies and α-synuclein, and increased the number of tyrosine hydroxylase positive cells. G