Protective effect of growth hormone-releasing hormone (GHRH) agonist MR-409 in Alzheimer’s disease
Giulia Morello, Francesca Pedrolli, Iacopo Gesmundo, Medhi Wangpaichitr, Wei Sha, Andrew V. Schally, Elena Tamagno, Michela Guglielmotto, Riccarda Granata · FENS Forum 2024
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the formation of amyloid-β (Aβ) plaques and Tau neurofibrillary tangles, leading to neuronal loss, inflammation, reduced neurogenesis, and cognitive impairment. Currently, there is no effective cure for AD, highlighting the urgent need for novel therapeutic strategies. Growth hormone-releasing hormone (GHRH) and its agonistic analog MR-409 exhibit several peripheral functions, including neuroprotection and protection against skeletal muscle atrophy. However, the role of GHRH in AD remains to be elucidated. Our in vitro f
ePoster · Neuroscience