Unraveling the interconnected functions of neurodevelopmental disorder-associated CYFIP2: from actin dynamics to membraneless organelle formation and protein synthesis regulation
Hyae Rim Kang, Yinhua Zhang, Yukyung Jun, Hyojin Kang · FENS Forum 2024
Recently, de novo CYFIP2 variants have been identified in individuals with neurodevelopmental disorders and epilepsy. Considerable progress has revealed CYFIP2’s role as a component of the WAVE regulatory complex controlling actin cytoskeleton dynamics in neuronal development and function. However, its molecular functions remain partially unresolved. In our previous study, we unexpectedly discovered RNA-binding proteins (RBPs) among the CYFIP2 interactome from the neonatal mouse forebrain, suggesting that CYFIP2 may have novel functions in RNA regulation potentially mediated by these RBPs. How
ePoster · Neuroscience