A food-sensitive olfactory circuit drives anticipatory satiety
Janice Bulk, Rui De Oliveira Beleza, André Carvalho, Ayden Gouveia, Lionel Rigoux, Anna-Lena Cremer, Heiko Backes, Sophie Marie Steculorum · FENS Forum 2024
Food sensory perception has emerged as a potent regulator of specialized feeding circuits; yet, the consequences on feeding behaviour and the underlying neuronal basis remain poorly understood. Here, we reveal a sensory pathway that coordinately integrates food odours to control forthcoming nutrient intake. Unbiased whole-brain mapping of food odours-induced brain activity revealed a potent activation of the medial septum (MS), where food odours selectively activate MS glutamatergic neurons (MSVGLUT2). Characterization of the activity dynamics of MSVGLUT2 neurons uncovered a biphasic modulatio
ePoster · Neuroscience