Inhibitory cell-type-specific properties and transformations set up a unique depth-dependent temporal integration scheme in the human neocortical circuit
Philip Wong, Yuan-Ting Wu, Dianna Hidalgo, Gabriel Kreiman, Costas A Anastassiou · COSYNE 2025
Inhibitory interneurons account for 20-30\% of neurons in the human neocortex (Markram et al. 2004) and separate into distinct cell-types (Gouwens et al. 2020, Lee et al. 2023). However, the functional role of these inhibitory cell-types is not yet well understood, especially not in the intact human neocortical circuit. Here we investigate the input-output transformations afforded by human inhibitory neurons as a function of cell-type compared to their rodent counterparts. To do so, we use multi-objective evolutionary optimization to develop approximately 4860 biophysically realistic and morph
ePoster · Neuroscience