Automated detection and analysis of spontaneous neurotransmitter releases from neurons and astrocytes
Wenli Niu, Yufan Chen, Xia Li, Olga Chaikovska, Sambre Mach, Juliette Royer, José Cancela, Sabir Jacquir, Micaela Galante, Matthieu Lerasle *, Glenn Dallérac * · FENS Forum 2024
Neuromodulators such as monoamines or neuropeptides play crucial roles in modulating diverse brain functions. They can be released phasically, i.e. in response to stimuli, or tonically, in a spontaneous and more discrete manner. Understanding how these spontaneous releases occur is challenging yet essential, as their disruption is associated with behavioral and psychiatric disorders. A paradigm shift in this domain has been the generation of fluorescent probes sensitive enough to detect, using 2-photons microscopy, discrete tonic release of specific neuromodulators including dopamine, noradren
ePoster · Neuroscience