Topic: multiple-timescale framework

Neuroplasticity refers to functional and structural changes in brain regions in response to healthy and pathological activity. Neuroplasticity induced by epileptic activity can involve healthy brain regions into the epileptogenic network by perturbing their excitation/inhibition balance. Here, we present a new neural mass model that accounts for neuroplasticity and that is used to investigate the possible mechanisms underlying the epileptogenic network expansion. We formulate physiological calcium-mediated synaptic plasticity and pathological structural plasticity in a multiple-timescale frame