Cav2.1 splice variants organize in nanodomains at presynaptic boutons where they differentially regulate synaptic vesicle release and synaptic facilitation
Asja Ragnini, Agnes Thalhammer, Fanny Jaudon, Jessica Muià, Lorenzo A. Cingolani, Gabriele Baj · FENS Forum 2024
Cav2.1 channels are critically important for fast synaptic transmission at central synapses. The two Cav2.1 isoforms Cav2.1[EFa] and Cav2.1[EFb] are generated by alternative splicing of two mutually exclusive exons, 37a and 37b. Both isoforms are expressed throughout the adult brain, whereas Cav2.1[EFb] predominates at early stages of development. Cav2.1[EFa] supports synchronous release and short-term synaptic depression, whereas Cav2.1[EFb] boosts asynchronous release and short-term facilitation. We investigated whether the two isoforms were distinctly located at excitatory nerve terminals r
ePoster · Neuroscience