Topic: Munc13

In synaptic transmission, the fast, precise, and synchronous release of neurotransmitters relies on a tight coupling between the synaptic release machinery, the synaptic vesicles, and the voltage-gated calcium channels (P/Q-type). Scaffolding molecules, including Rab-Interacting molecules (RIM), RIM-Binding Protein (RBP), ELKS, Munc13, Bassoon/ Piccolo, and Liprin-α are the main known regulators of this coupling. Specifically, RIM and RBP have been shown to uniquely regulate synaptic vesicle docking and fusion, since no synaptic activity remains in RIM/RBP-deficient neurons (Acuna et al, 2016)