Alternative splicing of Cav2.1 EF-hand contributes to the tightness of calcium influx-neurotransmitter release coupling at mouse cerebellar synapses
Kohgaku Eguchi, Le Monnier Elodie, Ryuichi Shigemoto · FENS Forum 2024
The coupling of voltage-gated calcium channels (VGCCs) and vesicular calcium sensors for neurotransmitter release is crucial for fast and efficient synaptic transmission. At parallel fiber (PF)-Purkinje cell (PC) synapses in mouse cerebellum, the coupling tightens during synaptic maturation in parallel with switching of splicing isoforms of the P/Q-type VGCC (Cav2.1) EF-hand from EFb to EFa. The Cav2.1[EFa] isoform has been reported to have a tighter Ca2+ influx-sensor coupling distance than the Cav2.1[EFb] isoform in hippocampal pyramidal neurons. Thus, the shift in the splicing Cav2.1-EF han
ePoster · Neuroscience