Topic: murine hippocampal slices

Astrocytes exhibit dynamic behavior in multiple sclerosis (MS), assuming both pro-inflammatory and anti-inflammatory phenotypes, yet their precise role in modelling the neuroinflammatory response in MS remains elusive. While mice are commonly employed for MS research, murine astrocytes fail to fully replicate the structural and functional complexity of their human counterparts, limiting the translation of findings from in vitro studies to the human context. Leveraging the unique characteristics of patient-derived iPSC astrocytes, this study aims to establish a platform for in vitro exploration