Parvalbumin interneurons protect peritumoral tissue from glioblastoma growth
Marta Scalera, Elisa De Santis, Arianna Sturlese Verduri, Nicolò Meneghetti, Noemi Barsotti, Elena Novelli, Alberto Mazzoni, Massimo Pasqualetti, Mario Costa, Matteo Caleo, Eleonora Vannini · FENS Forum 2024
While for many years cancer research has mainly focused on targeting tumoral cells, recent studies have confirmed that the tumor microenvironment (TME) plays a major role in controlling glioma growth. Indeed, several studies have highlighted that the synaptic activity of pyramidal, glutamatergic neurons potently drives Glioblastoma (GB) proliferation. However, the role played by other neuronal cell types is still poorly understood. Here, we wanted to dissect the role of peritumoral interneurons in GB development. Taking advantage of chemogenetics, we modulated the activity of parvalbumin (PV)-
ePoster · Neuroscience