In vitro treatment of rat primary hippocampal neurons with 17-α-ethinyl estradiol shapes synaptic spines: molecular, morphological and functional effects
Melania Maria Serafini, Miriam Midali, Fatemeh Aram, Emanuela Corsini, Marina Marinovich, Barbara Viviani · FENS Forum 2024
17-α-ethinyl estradiol (EE) is a semi-synthetic hormone and the main component of combined contraceptive pills and drugs with therapeutic indications such as hormone replacement therapy. In Europe and the USA, approximately sixty million women use oral contraceptives, and it is estimated that nearly two million unintended pregnancies occur each year due to medication errors, potentially exposing the embryo to EE during the first weeks of development. The hippocampus is a glutamatergic brain area expressing hormone receptors and hormones influence synaptogenesis. The development of glutamatergi
ePoster · Neuroscience