Topic: myelin debris

Spinal cord injury is associated with axonal damage and degeneration, leading to the dysfunction of neuronal networks and hence, severe impairment of neurological function. Injured neurons response depends both on extracellular cues (mainly non-permissive, such as myelin debris, extracellular matrix protein such as CSPG, glial and fibrotic scar, inflammatory cues, …) and their intrinsic capacity. How microtubule-associated protein (MAP) contribute to this response is the objective of the present work. MAP6 is the first neuronal microtubule (MT) inner protein discovered and preliminary results