Irisin levels in cerebrospinal fluid correlate with biomarkers and clinical dementia scores in Alzheimer’s disease
Manuela Dicarlo, Patrizia Pignataro, Chiara Zecca, Maria Teresa Dell'Abate, Daniele Urso, Valentina Gnoni, Alessia Giugno, Francesco Borlizzi, Roberta Zerlotin, Angela Oranger, Graziana Colaianni, Silvia Colucci, Giancarlo Logroscino, Maria Grano · FENS Forum 2024
A growing number of studies on mouse models of Alzheimer's disease (AD) and AD patients recently focused the attention on the neuroprotective effects of irisin, a myokine released by muscles upon exercise. Based on these findings, in the present study we aimed to investigate, in a large cohort of AD patients, the levels of irisin in the cerebrospinal fluid (CSF) and plasma, and their correlations with disease biomarkers. Biological samples were obtained from patients with Alzheimer's dementia (n=82), mild cognitive impairment (n=44) and subjective memory complaint (n=20) biologically character
ePoster · Neuroscience